According to our projections, the best bet against the spread in the NFL among Week 14’s 13 matchups is Cardinals -2.5 — for more tips, including parlay possibilities, scroll down.

NFL Picks Against the Spread – Week 14

Jump to Matchup:

Pick: Cardinals -2.5 vs. Seahawks

• Matchup: Seattle Seahawks at Arizona Cardinals
• Projected Winner & Margin: Cardinals by 6.2 points (Bet on this game at BetMGM)
• Spread: Cardinals -2.5
• Time: 4:05 p.m. ET
• Date: Dec. 8
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Pick: Lions -3.5 vs. Packers

• Matchup: Green Bay Packers at Detroit Lions
• Projected Winner & Margin: Lions by 9.1 points (Bet on this game at BetMGM)
• Spread: Lions -3.5
• Time: 8:15 p.m. ET
• Date: Dec. 5
• TV Channel: Amazon Prime Video
• Live Stream: Watch this game on Prime Video (Regional restrictions may apply)

Pick: Jaguars +3.5 vs. Titans

• Matchup: Jacksonville Jaguars at Tennessee Titans
• Projected Winner & Margin: Titans by 3.1 points (Bet on this game at BetMGM)
• Spread: Titans -3.5
• Time: 1 p.m. ET
• Date: Dec. 8
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Pick: Bears +4 vs. 49ers

• Matchup: Chicago Bears at San Francisco 49ers
• Projected Winner & Margin: 49ers by 3.9 points (Bet on this game at BetMGM)
• Spread: 49ers -4
• Time: 4:25 p.m. ET
• Date: Dec. 8
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Chiefs -4 vs. Chargers

• Matchup: Los Angeles Chargers at Kansas City Chiefs
• Projected Winner & Margin: Chiefs by 4.5 points (Bet on this game at BetMGM)
• Spread: Chiefs -4
• Time: 8:20 p.m. ET
• Date: Dec. 8
• TV Channel: NBC
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Bills -4.5 vs. Rams

• Matchup: Buffalo Bills at Los Angeles Rams
• Projected Winner & Margin: Bills by 9.0 points (Bet on this game at BetMGM)
• Spread: Bills -4.5
• Time: 4:25 p.m. ET
• Date: Dec. 8
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Giants +5 vs. Saints

• Matchup: New Orleans Saints at New York Giants
• Projected Winner & Margin: Saints by 2.4 points (Bet on this game at BetMGM)
• Spread: Saints -5
• Time: 1 p.m. ET
• Date: Dec. 8
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Vikings -5.5 vs. Falcons

• Matchup: Atlanta Falcons at Minnesota Vikings
• Projected Winner & Margin: Vikings by 14.7 points (Bet on this game at BetMGM)
• Spread: Vikings -5.5
• Time: 1 p.m. ET
• Date: Dec. 8
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Cowboys +5.5 vs. Bengals

• Matchup: Cincinnati Bengals at Dallas Cowboys
• Projected Winner & Margin: Bengals by 0.5 points (Bet on this game at BetMGM)
• Spread: Bengals -5.5
• Time: 8:15 p.m. ET
• Date: Dec. 9
• TV Channel: ESPN
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Steelers -6.5 vs. Browns

• Matchup: Cleveland Browns at Pittsburgh Steelers
• Projected Winner & Margin: Steelers by 17.2 points (Bet on this game at BetMGM)
• Spread: Steelers -6.5
• Time: 1 p.m. ET
• Date: Dec. 8
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Pick: Jets +6.5 vs. Dolphins

• Matchup: New York Jets at Miami Dolphins
• Projected Winner & Margin: Dolphins by 5.6 points (Bet on this game at BetMGM)
• Spread: Dolphins -6.5
• Time: 1 p.m. ET
• Date: Dec. 8
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Pick: Buccaneers -6.5 vs. Raiders

• Matchup: Las Vegas Raiders at Tampa Bay Buccaneers
• Projected Winner & Margin: Buccaneers by 19.0 points (Bet on this game at BetMGM)
• Spread: Buccaneers -6.5
• Time: 1 p.m. ET
• Date: Dec. 8
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Pick: Eagles -12.5 vs. Panthers

• Matchup: Carolina Panthers at Philadelphia Eagles
• Projected Winner & Margin: Eagles by 27.9 points (Bet on this game at BetMGM)
• Spread: Eagles -12.5
• Time: 1 p.m. ET
• Date: Dec. 8
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Catch every NFL touchdown with NFL RedZone on Fubo.

Not all offers available in all states, please visit BetMGM for the latest promotions for your area. Must be 21+ to gamble, please wager responsibly. If you or someone you know has a gambling problem, contact 1-800-GAMBLER.